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Thermo Scientific Talos Arctica – mid-range transmission electron microscope operating at 40 - 200 kV equipped with Schottky field emission gun (XFEG) providing highly coherent electron beam with ultimate stability. The microscope is equipped with Thermo Scientific Falcon3 EC direct electron detector and Ceta camera. Automated collection data for single particle analysis and cryo-electron tomography data can be performed with EPU or SerialEM software, respectively. The microscope is well suited for automated acquisition of high-quality cryoEM data, efficient screening of cryoEM samples, and 3D electron diffraction tomography

Modern electron microscopy in structural biology on the cellular and molecular level is performed by cryo-electron microscopy and cryo-electron tomography. Cryo-electron tomography (cryo-ET) is the only method to address pleiomorphic structures like cells and organelles in a close to native state, while cryo-electron microscopy (cryo-EM) is applied to study single particles, primarily larger macromolecular complexes, which have been isolated and purified by biochemical methods. Both methodologies provide information on the cellular and molecular level and are therefore ideal for in-depth structural-functional analysis in combination with state of the art biochemical characterisation.