Partner institution: |
3:MasarykUniversity-CEITEC |
Core facility: |
Biomolecular Interactions and Crystallization |
Category of instrument / technology: |
Interactions |
Web category: |
2 : characterisation |
Instrument name: |
Auto ITC200 |
Description EN: |
Fully automated isothermal calorimeter AutoITC200 with ultrasmall working cell (200 µl). ITC method is used for characterization of biomolecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and others. Enzyme kinetics, biological activity or the effect of molecular structure changes on binding mechanism can be also assessed. Complete thermodynamic profile of the molecular interaction in a single experiment (stoichiometry, Ka, ∆H and ∆S values). |
Part of research platform: |
The core facility provides services leading to biophysical and structure characterization of biomolecules and to study (bio)molecular interactions. It is equipped with the instrumentation to set up crystallization conditions of biomolecules and their complexes, basic characterization of physical properties of the molecules (analytical ultracentrifugation, dynamic light scattering, CD spectroscopy, differential scanning calorimetry, differential scanning fluorimetry), and to study thermodynamics and/or kinetics of interactions (isothermal titration calorimetry, surface plasmon resonance, microscale thermophoresis, CD spectroscopy, analytical ultracentrifugation). |
Name of instrument operator: |
Monika Kubíčková |
Email of instrument operator: |
monika.kubickova@ceitec.cz |
Supplier name: |
SPECION s.r.o. |
Price (excluding VAT) in EUR: |
239944 |
Year of purchase: |
2012 |
Year of installation: |
2012 |
Service contract Yes / No: |
0 |
Yearly price of service contract (excluding VAT) in EUR: |
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Capacity used in %: |
|
Running cont per hour of usage in EUR: |
11 |
Notes: |
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Tags: |
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